"BMP-Smad signaling regulates stem cell renewal, cell proliferation, differentiation, and postnatal tissue homoeostasis…These findings suggest that BMP-Smad pathway can be a potential target for osteoporosis..."

Endocr Metab Immune Disord Drug Targets. 2008 Sep

"…the bone morphogenetic proteins (BMPs) clearly play a central role in both bone cartilage formation and repair. Recent research into the regulation of the BMP pathway has led to the discovery of a number of small molecular weight compounds as candidate bone anabolic agents."

Curr Top Dev Biol. 2007;78

"...studies have reported that BMP-6 is the most effective inducer of osteogenic differentiation from mesenchymal stem cells…"

 Histochem Cytochem. 2008 June

"Bone morphogenetic proteins (BMPs) have been shown to stimulate bone formation, and the BMP2 gene was recently linked to osteoporosis..."

 Am. J Clin Nutr. 2006 Feb

"…systemically administered BMP-6 restored bone inductive capacity, microarchitecture, and quality of skeleton in an osteoporotic animal model."

The Journal of Biological Chem. 2006 Sep

"...because of their osteogenic potential, BMPs are of tremendous interest as therapeutic agents for healing fractures of bones, preventing osteoporosis, treating periodontal defects and enhancing bone formation..."

J Oral Sci. 2003 Jun 

"…different growth factors may have a specific role in regulating proliferation and differentiation of different stages of osteoblast lineage cells and play important roles in the local regulation of bone formation."

J Bone Miner Res. 1993 Dec

"…BMP-7 (Ostinol™) may be chondroprotective after traumatic injury in patients if it is administered within 3 to 4 weeks of the injury."

J Orthop Res. 2009 May

"Increasing evidence supports a critical role for BMP signaling in joint remodeling…cartilage homeostasis and repair"

Arthritis Res Ther. 2007

"…BMP-7 (OP-1) has the ability to repair cartilage …"

Int Orthop. 2007 Dec.

"BMP-4 and BMP-5 are expressed in normal synovial tissue and were found decreased in OA [osteoarthritis] and RA [rheumatoid arthritis]."

Arthritis Research & Therapy 2006 Mar

"...the presence of BMP-6 in adult human articular cartilage indicates a functional role for this growth factor in the maintenance of joint integrity."

Arthritis Rheum 2003 Sep

"...modulation of BMP signaling may be an attractive therapeutic target in chronic arthritis to restore homeostasis and function of synovial joints."

Cytokine & Growth Factor Reviews 2005 Apr

"Bone Morphogenetic protein 7 (bmp-7) stimulates proteoglycan synthesis in human osteoarthritic chondrocytes..."

Biomed Pharmacother. 2006 Dec

"...data suggest that BMP-2 may be a useful cytokine to improve healing of cartilaginous defects."

Plastic Reconstr. Surg. 2000 Mar