"BMP-Smad signaling regulates stem cell renewal, cell proliferation, differentiation, and postnatal tissue homoeostasis…These findings suggest that BMP-Smad pathway can be a potential target for osteoporosis..."
Endocr Metab Immune Disord Drug Targets. 2008 Sep
"…the bone morphogenetic proteins (BMPs) clearly play a central role in both bone cartilage formation and repair. Recent research into the regulation of the BMP pathway has led to the discovery of a number of small molecular weight compounds as candidate bone anabolic agents."
Curr Top Dev Biol. 2007;78
"...studies have reported that BMP-6 is the most effective inducer of osteogenic differentiation from mesenchymal stem cells…"
Histochem Cytochem. 2008 June
"Bone morphogenetic proteins (BMPs) have been shown to stimulate bone formation, and the BMP2 gene was recently linked to osteoporosis..."
Am. J Clin Nutr. 2006 Feb
"…systemically administered BMP-6 restored bone inductive capacity, microarchitecture, and quality of skeleton in an osteoporotic animal model."
The Journal of Biological Chem. 2006 Sep
"...because of their osteogenic potential, BMPs are of tremendous interest as therapeutic agents for healing fractures of bones, preventing osteoporosis, treating periodontal defects and enhancing bone formation..."
J Oral Sci. 2003 Jun
"…different growth factors may have a specific role in regulating proliferation and differentiation of different stages of osteoblast lineage cells and play important roles in the local regulation of bone formation."
J Bone Miner Res. 1993 Dec |