As early as 1984 research showed that individual BMPs stimulated cartilage growth from MSCs. This research lead scientists to look at the structure and function of both individual BMPs as well as the entire BMP-complex within joint and cartilage health
After pre-clinical studies, researchers demonstrated that the entire BMP-complex produced both new bone and cartilage growth. This demonstrated that the full, natural BMP-complex could stimulate and activate the mesenchymal stem cells at their DNA level to become new, active chondrocytes, producing cartilage tissue. This was the missing, critical, activating component needed so the body could absorb traditional nutrients such as glucosamine and chondroitin, and produce them into new, healthy cartilage tissue needed for joint function.
The process of activating mesenchymal stem cells and turning them into chondrocytes to produce bone tissue is known as osteoinduction (pronounced osteo-in-duction). It was discovered by Dr. Marshal Urist and published in the prestigious journal of Science in 1965. Today there is an entire medical industry known as osteobiologics from which surgeons can select osteoinductive products to re-grow bone and cartilage post-surgically.
The process of activating mesenchymal stem cells and turning them into chondrocytes to produce bone tissue is known as osteoinduction (pronounced osteo-in-duction).
The Research Continues
In 2003 researchers reported in the Journal of Arthritis and Rheumatism that BMP-6 indicates a functional role in the maintenance of joint integrity. In 2005 the Journal of Cytokines and Growth Factors reported that “modulation of BMP signaling may be an attractive therapeutic target for chronic arthritis to restore homeostasis and function of synovial joints.” Then, in 2006, two published studies further elucidated the role and critical need for BMPs in our joints every day. One showed that “BMP-7 stimulated proteoglycan synthesis [cartilage] in human articular chondrocytes [joint cells].” The second study published that year was in the journal of Arthritis Research and Therapy. It stated that “BMP-4 and BMP-5 are expressed in normal synovial tissue and were found decreased in OA [osteoarthritis] and RA [rheumatoid arthritis]”. This changed the understanding of the pathogenesis of arthritis. In some people, their bodies stop producing some of these BMPs. This lower level or absence of BMPs was now correlated with arthritis – meaning that our bodies need these BMPs each and every day to stimulate the stem cells to produce cartilage, otherwise we may develop arthritis!
…our bodies need these BMPs each and every day to stimulate the stem cells to produce cartilage, otherwise we may develop arthritis!
Researchers have shown that BMPs have a direct immunoprotective effect against IL-1, protecting the body against this pro-inflammatory cytokine, thus affecting inflammation at the beginning of the process.
The Inflammation Factor
Inflammation is a critical component in understanding how our bodies respond to and heal under various conditions. Interlukin-1 (IL-1) is a catabolic (breaking-down) protein instrumental in the inflammation cascade. IL-1 stimulates NFKappa-beta which in turn stimulates various collagenases including matrix metalloproteinases such MMP-1, MMP-8 and MMP-13. The net result of these biochemical reactions is seen clinically as edema and pain. Researchers have shown that BMPs have a direct immunoprotective effect against IL-1, protecting the body against this pro-inflammatory cytokine, thus affecting inflammation at the beginning of the process. By doing so, BMPs help our bodies control inflammation (and the associated pain) which accounts for their rapid clinical response when used orally.
In 2007 this novel BMP-complex was formally introduced into the natural healthcare arena by ZyCal Bioceuticals, Inc and is now known as Cyplexinol®. Cyplexinol® is the same, all natural, bio-active protein complex researched since 1965. It contains the same BMPs researchers have studied and published about in medical journals for 40 years, used surgically since 1991 in millions of patients, shown to work orally since 1993 and has been available to healthcare professionals and consumers since 2007 as Cyplexinol® Bone and Cartilage Stimulating Proteins!
Ostinol™, powered by Cyplexinol®, is a safe, powerful, and natural stem cell activator for all adults concerned about joint and cartilage health.
The Cellular Activator
Ostinol™ is the first supplement to contain Cyplexinol®, which contains the same BMP- complex proven to activate and stimulate mesenchymal stem cells into chondrocytes – the cells which absorb traditional nutrients (glucosamine and chondroitin) and “stitch” them together to produce the critically needed cartilage tissue so joints can move freely and work properly. Ostinol™, powered by Cyplexinol®, is a safe, powerful, and natural stem cell activator for all adults concerned about joint and cartilage health.
Since the proteins in Cyplexinol® (namely the BMPs) are shown to be actively involved in addressing inflammation, people report feeling better in days to weeks, not months! This clinical breakthrough, along with the cellular activation makes Cyplexinol® a unique and powerful, natural cartilage and joint product.
Putting it all Together
As we now understand, complete joint health requires nutrients or building blocks such as glucosamine and chondroitin, and activated cells, to absorb and put together these nutrients into cartilage. To meet the needs of those concerned about their joint health, ZyCal has developed Chondrinol® Osteoinductive Joint Supplement, the first nutritional supplement that increases the body’s ability to build and strengthen cartilage and joints the way nature intended.* It is scientifically formulated and clinically tested to help patients achieve maximum joint health benefits.*
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