FOR IMMEDIATE RELEASE:

Ostinol™ Activates Key Cells to Build Bone and Cartilage
New Protein Complex for Bone and Joint Health

Southborough, MA – June 11, 2007 – ZyCal Bioceuticals,Inc., specializing in nutritional supplements for bone and joint health, announced today the introduction of Ostinol™, a bone stimulating protein complex that activates key stem cells (mesenchymal cells) in the body to build bone matrix and cartilage.  Derived from certified organic cow bones, Ostinol™ Bone Stimulating Proteins contain Bone Morphogenetic Proteins (BMPs) and Transforming Growth Factor-beta (TGF-β) in a specialized collagen base.  These proteins are involved in stimulating the cells responsible for growing bone and cartilage.  Previous uses of BMPs include surgical implantation and direct application to the spine or a fracture site to promote fusion or bone healing.  Ostinol™ represents an innovation for bone and joint heath, delivering for the first time, a Bone Stimulating Protein complex as an oral nutritional supplement.  Ostinol™ will be available through healthcare providers without a prescription. Ostinol™ is for patients who are at risk of developing decreased bone mass, or are interested in maintaining good bone and joint health.  Patients will benefit from the protein’s ability to help the body naturally build bone and cartilage.  As clinical studies concluded, calcium has been shown to have limited benefits for bone health. Additionally, with the recently publicized adverse effects of pharmaceuticals COX-2 inhibitors for joint pain, ZyCal Bioceuticals’ Ostinol™ brings forth a paradigm shift in addressing bone and joint health naturally. "We are excited to offer our bone and cartilage stimulating proteins in response to market demand for more effective products and natural alternatives, stated James Scaffidi, ZyCal Bioceuticals’ Chief Executive Officer.  Ostinol™ Bone Stimulating Proteins provide an all natural bone and joint supplement solution that is complementary to professional healthcare and supporting of the "whole patient" concept, an integral aspect of treating patients with chronic conditions."

Ostinol™, when taken as a supplement in conjunction with a healthy lifestyle, is formulated to contribute towards long term bone and joint wellness. Ostinol™ Bone Stimulating Proteins are available in two nutritional supplements – Pro-Stiminol™ Osteoinductive Bone Supplement System and Chondrinol™ Osteoinductive Joint Supplement.  The Pro-Stiminol™ System contains two supplements - Ostinol™ Bone Stimulating Proteins and Tricalcidin-3™.  Ostinol™ activates key cells to build new bone matrix, while Tricalcidin-3™ with Vitamin D-3 fortifies and strengthens bone matrix.  Pro-stiminol’s™ dual action system is functionally involved in bone formation and fortification, and helps maintain bone homeostasis.  Chondrinol™ Osteoinductive Joint Supplement contains Ostinol™ to activate the key cells responsible to build cartilage, plus Glucosamine and Chondroitin to lubricate the joints and promote healthy joint function. Chondrinol™ promotes cartilage formation and helps maintain joint homeostasis.    

ZyCal Bioceuticals, Inc. has developed a proprietary complex of bone stimulating proteins that leverages BMPs (Bone Morphogenetic Proteins) first discovered by Dr. Marshall Urist in 1965.  The company’s founding follows 40 years of BMP research and 20 years of clinical use, and is based upon Urist’s discoveries of the principles that bone regenerates itself through key proteins that stimulate cells to grow bone and cartilage.

About ZyCal Bioceuticals, Inc.

ZyCal Bioceuticals, Inc. specializes in developing and marketing premium bone and joint health supplements based upon its proprietary formulation of bone and cartilage stimulating proteins.  Founded in 2006, the company’s products enable patients to achieve better bone and joint health through biologically active nutritional supplements.  The company’s scientific expertise is supported by solid clinical leaders, key scientists, industry expert consultants and medical educators, all committed to providing the highest level of professionalism and responsiveness as a dedicated partner to healthcare providers.